Japanese Society for Process Chemistry

 
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JSPC Award for Excellence
    
2012 Summer Symposium Awardees

Atsushi Akao*, Yusuke Miyashita, Hiroshi Oe, Yuki Kosaka, Jun Nishijima and Masaaki Hori
(API Research, Eisai Product Creation Systems)
Reaction Analyses / Monitorings by LC-MS; Toward Process Understandings

Masayuki Utsugi*, Hiroki Ozawa, Masanori Hatsuda
(Process Chemistry Research Laboratories, CMC Division, Mitsubishi Tanabe Pharma Corporation)
Scale-up Studies on Synthesis of Benzonitrile Derivarive via Pd-Catalyzed Cyanation

Shun Hirasawa*, Kazuyoshi Obitsu, Kazuhiro Takeguchi, Ryoki Orii, Shigeru Ieda, Minoru Okada
(Process Chemistry Laboratories, Astellas Pharma Inc.)
Polymorphic Control of Novel ALK Inhibitor ASP3026 via Solvent-Mediated Polymorphic Transformation

Tsubasa Sakamoto*, Keiji Mori, Takahiko Akiyama
(Department of Chemistry, Faculty of Science, Gakushuin University)
Phosphoric Acid Catalyzed Enantioselective Transfer Deutration of Ketimines by Use of Deutrated Benzothiazoline

JSPC Award for Excellence(2011〜2002)

2012

Oct. 10, 2012 updatenew
JSPC 2012 Winter Symposium

December 7, 2012
12:30-17:15 (Symposium), 17:45-19:45 (Banquet)
GRANSHIP Shizuoka
Organizer: Masaru Mitsuda (Kaneka), Shuji Akai (Univ. of Sizuoka)

<Invited Lecture>

  1. Global trends in biocatalysis and its contributions to chemical processes
    Yoshihiko Hirose
    (Medical Enzyme Division, Amano Enzyme Inc.)
    Chair : Toshihisa Kato (Ajinomoto)

  2. Spiro-carbon formation via common epoxidation strategy in uncommon pathway crosstalk
    Kenji Watanabe

    (Department of Pharmaceutical Sciences, University of Shizuoka)
    Chair : Toshiaki Mase (Meiji Seika Pharma)

  3. Unnatural amino acid production using biocatalysis as key reactions
    Mari Hara Yasuda

    (Healthcare Business Division, API Corporation) 
    Chair : Yoshihiko Yasohara (Kaneka)

  4. Development of new enzymatic reactions and their practical applications
    Yasuhisa Asano

    (Biotechnology Research Center and Department of Biotechnology; ERATO, JST, Toyama Prefectural University)
    Chair : Toshiro Konoike (Shionogi)

<JSPC Award for Excellence 2012 Lecture>   Chair : Naotsuka Hikage (Daiichi-Sankyo)

  1. Reaction Analyses / Monitorings by LC-MS; Toward Process Understandings
    Atsushi Akao*, Yusuke Miyashita, Hiroshi Oe, Yuki Kosaka, Jun Nishijima and Masaaki Hori
    (API Research, Eisai Product Creation Systems)

  2. Scale-up Studies on Synthesis of Benzonitrile Derivarive via Pd-Catalyzed Cyanation
    Masayuki Utsugi*, Hiroki Ozawa, Masanori Hatsuda
    (Process Chemistry Research Laboratories, CMC Division, Mitsubishi Tanabe Pharma Corporation)

  3. Polymorphic Control of Novel ALK Inhibitor ASP3026 via Solvent-Mediated Polymorphic Transformation
    Shun Hirasawa*,
    Kazuyoshi Obitsu, Kazuhiro Takeguchi, Ryoki Orii, Shigeru Ieda, Minoru Okada
    (Process Chemistry Laboratories, Astellas Pharma Inc.)

  4. Phosphoric Acid Catalyzed Enantioselective Transfer Deutration of Ketimines by Use of Deutrated Benzothiazoline
    Tsubasa Sakamoto*,
    Keiji Mori, Takahiko Akiyama
    (Department of Chemistry, Faculty of Science, Gakushuin University)

■more info >>http://www.kagakukogyonippo.com/ent/process_w/index.html (Japanese Site)

 

JSPC 2012 Summer Symposium

July 19-20, 2012
Kyoto Terrsa
Organizer: Kazuhiko Takahashi (Dainippon Sumitomo), Kiyomasa Takasu (Kyoto Univ.)

<Invited Lecture>

     【July 19 (Thur.)】

  1. Process Development of an azole-type antifuangal intermediate
    Masaru Mitsuda
    (Frontier Biochemical & Medical Research Laboratories Kaneka Corporation) 
    Chair : Katsuya Tagami (Eisai)

  2. Reaction Developments for Synthetic Issues of Process Chemistry
    -The selective addition of Grignard reagents to the ester group of active methylene compound, and the selective halolactonization of di-olefin compound followed by regeneration of olefin are described.
    Masatoshi Murakata
    (API Process Development Dept., Chemical Tecnology, Chugai Pharmaceutical Co., Ltd.) 
    Chair : Shoji Maruyama (Tanabe Mitsubishi)

  3. Development of Organocatalysts on the Basis of Hydrogen Bonds as Strategic Intereaction
    Masahiro Terada
    (Department of Chemistry, Graduate School of Science, Tohoku University) 
    Chair : Tetsuya Ikemoto (Sumitomo Chemical)

  4. Industrially Applicable Leading-Edge Homogeneous Precious Metals Catalysts
    - Featuring Palladium Catalysts for Cross-Coupling Reactions -
    Yoshiaki Horiguchi
    (Precious Metals Chemistry, Umicore Japan KK) 
    Chair : Tsuyoshi Tagata (Koei Chemical)

  5. Development of New Reagents Based on 1,3,5-Triazine
    Munetaka Kunishima
    (Fucalty of Pharmaceutical Science, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University)
    Chair : Toshihisa Kato (Ajinomoto)

    【 July 20 (Fri.)】

  6. Process Development for Razupenem (SMP-601)
    Mikio Sasaki
    (Technology R&D Management, Dainippon Sumitomo Pharma Co., Ltd.)
    Chair : Toshiaki Mase (Meiji Seika)

  7. Process Research of a p38 MAP Kinase Inhibitor Using Lipase-catalyzed Enantioselective Hydrolysis as a Key Reaction
    Shinya Yoshida
    (Process Chemistry Labs., Astellas Pharma Inc.)
    Chair : Naoyuki Kishi (Daiichi Sankyo)

  8. Scalable Processes to Pharmaceutical Intermediates and APIs Using Evolved Enzymes
    Steve Collier(Codexis)  
    Chair : Hiroshi Kawabata (API Corporation)

  9. Scavenging Technologies from Johnson Matthey
    Suguru Minami (Johnson Matthey Japan)  
    Chair : Takao Saito (Takasago International Corporation)

  10. PAT and QbD for API based on case-studies in US
    Katsuhisa Hirano
    (LIMS Business Department, CTC Laboratory Systems Corporation) 
    Chair : Hideyuki Kitamura (Shionogi)

  11. Synthesis of Polyketide-derived Natural Products
    Kozo Shishido
    (Graduate School of Pharmaceutical Sciences, The University of Tokushima)
    Chair : Masahiro Kajino (Takeda)

Thank you very much for your interest and participation.

■more info >>http://www.kagakukogyonippo.com/ent/process/

 
The Pharmaceutical Society of Japan (PSJ)132nd Symposium:Process Chemistry to Innovate Drug Discovery

March 30, 2012,
9:00〜12:00
Hokkaido University
Organizer : Toshiro Konoike, Mitsuru Shindo

<Invited Lecture>

  1. Kazuhiko Takahashi
    (Dainippon Sumitomo Pharma)

  2. Yasushi Matsumura
    (Asahi Glass)

  3. Satoshi Ichikawa
    (Hokkaido Univ.)

  4. Hayao Matsuhashi
    (GlaxoSmithKline)

  5. Hironao Sajiki
    (Gifu Pharmaceutical Univ.)

2011

 
JSPC 2011 Winter Symposium

Dec. 9, 2012,
12:30-17:00 (Symposium), 17:30-19:30 (Banquet)
The University of Tokyo
Organizer : Masahiro Kato (Chugai), Motomu Kanai (The Univ. of Tokyo)

<Invited Lectures>

  1. Development of Microreactor System and Successful Cases of Process Innovation
    Shigenori Togashi

    (Hitachi, LTD., Hitachi Research Laboratory)

  2. Recent Progress in Organic Synthesis Using Flow Reaction Devices
    Ilhyong RYU
    (Department of Chemistry, Osaka Prefecture University)

  3. Fine Organic Synthesis by Using Ynoaltes C
    Mitsuru Shindo
    (Institute for Materials Chemistry and Engineering, Kyusyu University)

  4. Moffatt-Swern Oxidation at Room Temperatures Using Continuous Microflow Systems : A Practical Approach to Manufacturing of Pharmaceutical Intermediate
    Hiroyuki Miyata
    (Organic Chemistry Research Laboratory, Corporate Research & Development, Ube Industries, Ltd)

<JSPC Award for Excellence 2011 Lecture>

  1. One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether
    Hayato Ishikawa, Masakazu Honma, Yujiro Hayashi*
    (Tokyo University of Science, Japan)

  2. Development of a practical synthesis for HDAC Inhibitor AS1623879-CL
    Ryoki Orii*, Takashi Kikuchi
    (Astellas Pharma Inc., Japan)

  3. Development of a Novel Liquid-Phase Peptide Synthesis (LPPS) on Anchors Bearing a Long Aliphatic Chain: AJI-PHASETM
    Daisuke Takahashi*
    (AJINOMOTO Co., Inc. Japan)

  4. Asymmetric Synthesis of Allyl Esters via Vanadium-Lipase Combo Catalyzed Dynamic Kinetic Resolution.
    Masahiro Egi1), Koji Sugiyama1)*, Moriaki Saneto1), Ryosuke Hanada1), Katsuya Kato2), Shuji Akai1)
    [(1)University of Shizuoka, Japan, (2)National Institute of Advanced Industrial Science and Technology, Japan]

The 2nd International Symposium on Process Chemistry [ISPC 2011]

Kyoto International Conference Center
Aug 10 (Wed) - 12 (Fri), 2011
Chairperson of ISPC 2011 Hironao Sajiki (Gifu Pharm. Univ.)

<Keynote Lecture>

     【August 11 (Thur.)】

  1. Development of Sustainable Manufacturing Processes: A Transaminase-based Synthesis of Sitagliptin
    David L. Hughes (Merck, USA) : speaker changed from Skip Volante (Merck, USA)
    Chair: Ichiro Shinkai (Consultant, Japan)

  2. Rh/Ru Dual Catalyst for the Tandem Hydroformylation/Hydrogenation Reaction
    Kyoko Nozaki (Univ. of Tokyo, Japan)
    Chair: Toshiaki Mase (Meiji, Japan)

  3. Catalytic Shortcuts Enable Severe Carbon Footprint Reductions in the Production of Chiral Intermediates and API's
    Andre H. M. de Vries (DSM Pharmaceutical Products, The Netherlands)
    Chair: Toshihisa Kato (Ajinomoto, Japan)

  4. Process Development of Eribulin Mesylate (HALAVEN(tm))
    Katsuya Tagami (Eisai, Japan)
    Chair: Yoshiharu Iwabuchi (Tohoku Univ., Japan)

  5. Molecular complexity vs. cost, applications to the synthesis of gamma amino acids
    Tamim Braish (Pfizer, USA)
    Chair: Takahiko Akiyama (Gakushuin Univ., Japan)

  6. Practical Catalytic Asymmetric Synthesis of Drug Candidates
    Masakatsu Shibasaki (The Microbial Chemistry Research Foundation, Japan)
    Chair: Naotsuka Hikage (Daiichi Sankyo, Japan)

    【August 12 (Fri)】

  7. Design of New, Efficient, Green Catalytic Reactions Based on Pincer Complexes
    David Milstein (The Weizmann Institute of Science, Israel)
    Chair: Kin-ichi Tadano (Keio Univ., Japan)

  8. New Developments of Organyl Zinc Reagents for Cross- Couplings Reactions
    Joachim Schmidt-Leithoff (BASF, USA)
    Chair: Hidetsura Cho (Tohoku Univ., Japan)

  9. Catalytic C-H Bond Functionalization of Heterocycles for the C-C and C-N Bond Formation
    Sukbok Chang (KAIST, Korea)
    Chair: Kozo Shishido (Univ. of Tokushima, Japan)

  10. Development of a new chemical class of insecticide, flubendiamide, and its process chemistry
    Kenji Tsubata (Nihon Nohyaku, Japan)
    Chair: Mitsuru Shindo (Kyushu Univ., Japan)

  11. A Case Study on Rapid Development and Scale-up to Manufacture Kilogram Quantities
    Donald Hou (China Gateway Pharmaceutical Development, China)
    Chair: Minoru Okada (Astellas, Japan)

  12. Journeys towards Simplicity: Case Studies in Process Chemistry
    Tony Y. Zhang (Eli Lilly, China)
    Chair: Masahiro Kato (Chugai, Japan)

  13. Can Flow Chemistry Help?
    Steven Ley (Cambridge Univ., UK)
    Chair: Takayuki Shioiri (Nagoya City Univ., Japan)

URL: http://www.chemicaldaily.co.jp/ent/ispc2011/index.html

This symposium came to an end with great success by 916 people participating. Thank you very much for a lot of cooperation of participant. All the programs have ended for ISPC2011. We hope to see you again at the next ISPC2015.

■Website>>    ■JSPC Award for Excellence 2011>>   ■Photo Gallery>>


The symposium was cancelled.
The Pharmaceutical Society of Japan (PSJ)131st Symposium : Process Chemistry Directed toward Drug Discovery

March 30, 2012
9:30-12:30
Granship Shizuoka
Organizer : Mitsuru Shindo (Kyusyu Univ.), Toshiro Konoike (Shionogi)

<Invited Lectures>

  1. Takao Abe
    (Meijiseika)

  2. Yasusi Matsumura
    (Asahi Glass)

  3. Hidetoshi Kitagawa
    (Nippon Shinyaku)

  4. Hayao Matsuhashi
    (GlaxoSmithKline)

  5. Hironao Sajiki
    (Gifu Pharmaceutical Univ.)

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2010

 
JSPC 2010 Winter Symposium

Dec. 3, 2010
WINC AICHI
Organizer: Hironao Sajiki (Gifu Pharmaceutical Univ.), Koji Kagara (OHARA Pharmaceutical)

<Invited Lectures>

  1. New Method for Production of Homocystine as Pharmaceutical Intermediate
    Jun Takehara
    (Biotechnology Laboratory, Mitsubishi Chemical Group Science and Technology Research Center, Inc. Bio & Chemical Process Discovery Laboratory, API Corporation)

  2. The First Example in the World of Semi-Synthetic Aminoglycoside Antibiotic Production
    Keiichi Ajito*, Eijiro Umemura and Yasushi Murai
    (Pharmaceutical Company, Meiji Seika Kaisha Ltd.)

  3. Heterogeneous Transition Metal Catalysis Water toward Clean Organic Synthesis
    Yasuhiro Uozumi
    (Insutitute for Molecular Science)

  4. For the Further Development of Process Chemistry
    Takayuki Shioiri
    (Faculty of Agriculture, Meijo University)

<JSPC Award for Excellence 2010 Lecture>

  1. Process deveropment of AZADO-catalyzed oxidation - Experimental demonstration by pirot scale production -
    Shunsuke Fukuya*, Michiharu Handa, Katsuya Sakata, Hiroyuki Kotajima, Motoi Otani
    (Onda Plant, Technical Deveropment Division, Nissan Chemical Industries, Ltd., Japan)

  2. Deveropment of Novel Phosphoramidite Monomer for Oligo RNA Synthesis
    Hirofumi Maeda*, Akio Fujii, Masaru Mitsuda
    (Frontier Biochemical& Medical Research Labratories, Kaneka Corporation, Japan)

  3. Catalytic Asymmetric Synthesis of R207910
    Yutaka Saga*, Rie Motoki, Sae Makino, Yohei Shimizu, Motomu Kanai, Masakatsu Shibasaki
    (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan)

Thank you very much for your interest and participation.


 
JSPC 2010 Summer Symposium

July 15-16, 2010
Tower Hall Funabori
Organizer: Kin-ichi Tadano (Keio Univ.), Kiyotomo Seto (Nissan Chemical Industries)

<Invited Lectures>

  1. Asymmetric Catalysis Using Hard Anion-Conjugated Chiral Cu(I) Salts
    Motomu Kanai
    (Graduate School of Pharmaceutical Sciences, The University of Tokyo)
    Chai r: Hironao Sajiki (Gifu Pharmaceutical Univ.)

  2. Safety Assessment and Quality Control in Oxidation Reaction Process
    Yasuhiro Takahashi
    (Chemical Research Laboratories, Nissan Chemical Industries, Ltd.)
    Chair : Toshiaki Mase (Meiji Seika)

  3. Control of Impurities and Point of view in Processing Design
    Hiroaki Nagaoka
    (Faculty of Pharmaceutical Sciences, Nagasaki International University)
    Chair : Kin-ichi Tadano (Keio Univ.)

  4. Use of Micro Space for Formation and Conversion of High Reactive Compounds for Example Nitro Compounds
    Toshihiko Ohta
    (taketoyo Plants Aichi Works NOF Corp.)
  5. Hideyuki Nagasawa
    (Dalton)
    Chair : Shigeru Soda (Eisai)

  6. Rh(II)-Catalyzed Asymmetric Ring Forming Reactions
    Shunichi Hashimoto
    (Faculty of Pharmaceutical Sciences, Hokkaido University)
    Chair : Kiyoshi Tomioka (Doshisha Women's College of Liberal Arts)

  7. Safety Evaluation Technology for Scale-up of Chemical Process
    Yoichi Kunito
    (Safety Engineering and Environmental Integrity Laboratory, Production Technology Laboratory Mitsubishi Chemical Group Science and Technology Research Center, Inc.)
    Chair : Masahiro Oshima (Tanabe Mitsubishi)

  8. Development of Novel Enantioselective C-C Bond Forming Reactions Promoted by Dual Activation Type Organocatalyst
    Hiroaki Sasai
    (The Institute of Scientific and Industrial Research (ISIR), Osaka University)
    Chair : Yoo Tanabe (Kwansei Gakuin Univ.)
  9. The Application of Laboratory Automation and Process Analitical Technology in Shionogi
    Tomohiro Unno
    (Innovative Drug Discovery Research Laboratories., Shionogi & Co., Ltd.)
    Chair : Takumi Tanaka (Wako)

  10. Short-Lived Chiral Enolate Intermediates for Concise Asymmetric Synthesis of Heterocycles with Tetrasubstituted Carbon Starting from Amino Acids and Lactic Acid
    Takeo Kawabata
    (Institute for Chemical Research, Kyoto University)
    Chair : Toshiro Konoike (Shionogi)

  11. Analytic point of view of the Process Hazard Analysis Methodology used in Chemical Process Industry-Aiming Quality as well as Safety
    Hiroshi Sumida
    (Design HSE Department, HSE Engineering Division, Plant Engineering Center, Toyo Engineering Corporation)
    Chair : Koji Kagara (Ohara)
■2010 JSPC Award for Excellence>>

 
The Pharmaceutical Society of Japan (PSJ)131st Symposium : The Industrial Aspects of Process Chemistry

March 29, 2010
9:00-12:00
Okayama University
Organizer: Yusaku Yokoyama, Masaya Ikunaka

<Invited Lectures>

  1. Atsushi Ohigashi (Astellas)

  2. Noriaki Maruyama (Chugai)

  3. Misayo Sera (Takeda)

  4. Iwao Okamoto (Hayashibara)


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The Japanese Society for Process Chemistry